Stem cell transplantation for paroxysmal nocturnal haemoglobinuria in childhood.
نویسندگان
چکیده
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic disorder characterized by chronic or intermittent intravascular haemolysis, variable cytopenia and an increased risk of thrombosis. Stem cell transplantation (SCT) is a curative therapeutic option, but its risks must be carefully weighed against the natural course of PNH. World-wide experience with SCT for PNH in the paediatric age group is scarce. We report on two adolescents suffering from PNH with life-threatening complications who were successfully transplanted from unrelated donors. Indications and techniques of SCT in childhood PNH are discussed and an overview of the literature is given.
منابع مشابه
Paroxysmal nocturnal haemoglobinuria and Budd-Chiari syndrome.
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ورودعنوان ژورنال:
- British journal of haematology
دوره 118 1 شماره
صفحات -
تاریخ انتشار 2002